منابع مشابه
Antiganglioside antibodies in paraneoplastic peripheral neuropathies.
A total of 29 patients with cancer and neuropathies of unknown origin that were possibly paraneoplastic were tested for antiganglioside antibodies by immunodot blot and ELISA. None of the patients had onconeural antibodies. They were compared with 41 normal subjects and 187 patients with metabolic or idiopathic neuropathies. Antiganglioside antibodies, mainly IgM anti-GM1, were more frequently ...
متن کاملGangliosides act as onconeural antigens in paraneoplastic neuropathies.
We describe two patients with progressive neuropathy and lung cancer in whom gangliosides (GS) may represent the oncoantigens. Patient 1 had motor neuropathy, high titers of IgG1 and IgG3 to GD1a and GM1, and expansion of circulating gamma-delta T lymphocytes, a T-cell subset responding to glycolipids. Patient 2 presented with Miller-Fisher-like syndrome and IgG3 activity to disialo-GS. In both...
متن کاملAntinuclear antibodies define a subgroup of paraneoplastic neuropathies: clinical and immunological data.
OBJECTIVE Paraneoplastic neuropathy is a clinical and immunological heterogeneous disorder and attempts have been made to classify subgroups of this disease. Only 30-50% of the clinical defined cases have antineuronal antibodies. METHODS The clinical and immunological features of 36 patients with paraneoplastic neuropathy from the authors' database were analysed including the type and course ...
متن کاملParaneoplastic Retinopathies and Optic Neuropathies vs. (non-cancer) Autoimmune Related Retinopathy and Optic Neuropathy (arron Syndrome)
CME QUESTIONS 1. For patients with cancer-associated retinopathy, all of the following are true except one: a. They typically have a severely reduced ERG b. They usually display a marked loss of vision c. They often have photopsias d. Small cell carcinoma of the lung is one of the more common associated tumors e. The visual loss is easily treated with appropriate immunologic therapy 2. All of t...
متن کاملPain as a First Manifestation of Paraneoplastic Neuropathies: A Systematic Review and Meta-Analysis
INTRODUCTION Paraneoplastic neurological syndromes (PNS) consist of a heterogeneous group of neurological disorders triggered by cancer. The aim of this systematic review is to estimate the reported prevalence of pain in patients with paraneoplastic peripheral neuropathy (PPN). METHODS A systematic computer-based literature search was conducted on PubMed database. RESULTS Our search strateg...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 2019
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.108.1562